Why is the liver so weirdly regenerative?

(dynomight.substack.com)

56 points | by jbotz 2 hours ago

9 comments

  • vconnor 32 minutes ago
    The punishment for Prometheus stealing fire from the Gods and gifting it to humanity, was to be chained to a rock and having an eagle feed on his liver which would regrow the next day.
    • bheadmaster 14 minutes ago
      For what it's worth, Prometheus was a Titan, and Titan was immortal, so his liver regrowing the next day wasn't really that special. If eagle fed on his heart, or lungs, they would've regrown too.

      The Greeks chose liver because it symbolized the defiance Prometheus had against gods.

      • seizethecheese 13 minutes ago
        Why would liver signal defiance?
        • jephs 1 minute ago
          There are a bunch of Japanese words (including a several loanwords from Chinese) that use the liver / gallbladder metaphorically for courage. Both derive from associations between the humours and personality / behavior. I have no idea, however, why both Eastern and Western naive psychology associate gall with, well, gall.
        • Sleaker 1 minute ago
          It was the believed area of emotion, passion and 'soul'. I think western/modern religion has morphed from the liver to the heart essentially.
        • Bluestein 5 minutes ago
          Humors perhaps. Not my area, so I do not recall the correspondence ...
      • bell-cot 5 minutes ago
        I'm thinking the Greeks chose liver because it is the first thing that many predators will eat from a kill - large, more nutrient-dense than almost any other tissue, and relatively quick to access.
  • warumdarum 2 minutes ago
    Because alcoholism forces hunter gatherer cultures into settlements, which are the next stage of civilization and reward those doing that choice?
  • Aeolun 20 minutes ago
    I feel like this is obvious. Eventually dying of all the weird body failures doesn’t inhibit your ability to procreate, but if you cannot survive alcohol or other various poisons you’ll never make it to a fertile age.
    • nomel 0 minutes ago
      Picking the wrong berry from a bush isn't so difficult. Ask me how I know.
  • amluto 1 hour ago
    The lack of heart cancer might be more complex than the OP imagines:

    https://www.science.org/content/blog-post/no-heart-cancer-th...

    • jaggederest 31 minutes ago
      Other animals do get heart cancer, which is fascinating. It's still very uncommon compared to other cancers, but not virtually absent as it is in people.
  • schnuri 1 hour ago
    I am in awe about how wonderfully engineered by evolution the body is. E.g., what we are able to do with it and how it heals itself when we have an injury. Sure, many people would not live long without external intervention, but many others would. I still want to see the robot that can survive 80 active years without maintenance.
    • dgunay 47 minutes ago
      Well, we do at least have to eat enough food and sleep ~1/3rd of our lives. That's kinda maintenance
      • micromacrofoot 34 minutes ago
        that's absolutely maintenance, without it you have a total system failure in a week
    • ericmay 36 minutes ago
      When you watch those sci-fi shows and folks have nanobots implanted in them that heal wounds really fast or do other cool things I can't help but think in many ways we already have that technology we just need it to do more, faster as our brains and ability to create things have outpaced the rate of evolutionary change.
    • RobotToaster 46 minutes ago
      Humans don't last long without topping up their fluids and consumables.
    • markyc 53 minutes ago
      no you don't
    • chistev 54 minutes ago
      The human body can't survive 80 active years without maintainance. They take drugs, they see the doctor, etc.
      • CookieCrisp 48 minutes ago
        What did people do 500 years ago?
        • EduardoBautista 46 minutes ago
          Die as a child at alarming rates
          • lukan 41 minutes ago
            But those who did not, got quite old without ever seeing a doctor.

            (If we are talking about hunter gatherers, not poor exploited peasants)

            • steve_adams_86 1 minute ago
              Humans have assisted each other medically, supported injured and disabled tribe members, and sought out medicinal herbs since long before history was written. I'm not sure how you'd delineate between modern health care and when humans never had some notion of health care and/or support when bodies enter failure modes. We don't survive well without a lot of assistance and care.
            • 1attice 26 minutes ago
              Citation required
              • Fezzik 2 minutes ago
                Gurven, Michael & Hillard Kaplan (2007). “Longevity Among Hunter-Gatherers: A Cross-Cultural Examination.” Population and Development Review, 33(2), 321–365

                If you made it past age 5 as a hunter-gatherer you’d likely live to 50-60 years of age.

  • agumonkey 29 minutes ago
    Anybody on HN knows platforms to discuss this ?
    • gchamonlive 25 minutes ago
      This is a platform and we are discussing this, which means such a platform isn't enough for what you need. Not judging, actually I've felt a degradation in engagement quality as of late, maybe it's personal bias, but the discussions seem more shallow or aggressive.

      In any case, what would you expect from such a platform? That would help with recomendations.

  • card_zero 1 hour ago
    > Evolution decided the good outweighed the bad, and I expect that evolution was right.

    We can expect evolution to do the right thing for the genes. Not for us.

    • cortesoft 51 minutes ago
      I get its just a framework to understand what is happening, but I always hate the phrasing of describing a 'decision' to a process like evolution. There are no decisions being made in the process, just a series of outcomes that lead in a direction
      • someonebaggy 36 minutes ago
        Evolution is literally just the observation that there are lots of things that self-replicate.

        That's it. That's the entire thing. Plus some nuance about things that self-replicate faster than other things...

        It occurs at all levels. Amyloid protein in Alzheimer's patients is self-replicating. So are cells. So are individual parts of cells. Sometimes things replicate by being parts of a larger thing that replicates, sometimes they don't. It's all one big chaotic tangled mess with no particular purpose or design. Human cells evolve, so do humans, so do human societies. So do rocks.

        • cwillu 32 minutes ago
          Rocko can't have kids, because Rocko is just a stupid rock.
      • CookieCrisp 44 minutes ago
        Indeed, I’ve heard so many people misunderstand it because of this type of wording. Like there is still some plan and series of steps we’re following - which really misses the whole point and why it’s worth knowing in the first place
  • bbor 1 hour ago

       I greatly resent having to be a biological organism and subject to all the poor engineering and design decisions that entails.
    
    The first word of that sentence implies its absurdity quite beautifully. She resents, therefor she is.

    And then this:

      Brains. After you reach adulthood, neurons don’t divide. If some of your neurons die—which happens every day—then they’re gone. If you get a brain injury, the other neurons will try to “learn around” the injury, but the neurons themselves are never replaced.
    
    We need more neuroscience in schools! This summary is technically correct ofc, but to imply that the brain is missing some obviously-better option is absurd. We're meat that thinks, y'all; it's far from crap.
    • someonebaggy 34 minutes ago
      IIRC the slow loss of neurons is more than balanced by the additional fine-tuning - unless you get dementia, if course.

      Loss of neurons isn't disastrous as long as it's not too many. Babies are born with several times more neurons than children have, and spend a few months letting all the useless ones die. Apparently it's better to start with a random tangle and prune it to shape (like cutting a box hedge) than to make a hedge grow in a box shape to begin with.

      And IIRC brains can grow more neurons under some circumstances (certain drugs?) - they just normally don't.

      • rzzzt 19 minutes ago
        "While questions remain regarding the precise extent, rate, and functional relevance of adult neurogenesis in the human brain, as well as important methodological considerations, multiple independent approaches now converge in support of its persistence throughout adulthood."

        https://www.sciencedirect.com/science/article/pii/S193459092...

    • dekhn 8 minutes ago
      the claim isn't complete, either. Recent research has demonstrated adult neurogenesis (growth of new cells that originate from neural stem cells).
    • done_lurking 23 minutes ago
      Why is it absurd to say that the human brain could be better? That seems obviously true to me.
  • dekhn 1 hour ago
    [flagged]
    • dang 1 hour ago
      "Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something."

      https://news.ycombinator.com/newsguidelines.html

    • rwmj 1 hour ago
      I can't judge if you are correct or not. It would be more convincing if you could name some of the problems. Since the article is "garbage", there should be lots of things wrong to choose from.
    • haskellandchill 1 hour ago
      I agree. Very shallow "sources" and no qualifications to be speaking on a medical topic. There is a role for pop science to disseminate knowledge but this is pure speculation.
      • dang 31 minutes ago
        There's nothing wrong with speculation on HN. Speculation is intimate with curiosity, and curiosity, not correctness, is the guiding value of this site.

        It may sound odd to demote correctness, but it doesn't mean we value incorrectness. Correctness is good, just not at the top of the hierarchy. Curiosity—specifically, intellectual curiosity—is what we're optimizing for (https://hn.algolia.com/?dateRange=all&page=0&prefix=true&sor...).

        We value the freedom to meander around topics in a curious way. Of course this means following paths that turn out to be wrong [1], but that is how new things are learned, and it's a good way to spend time. People are allowed to be wrong on HN [2]. It's part of figuring out what's true. Truth is crucial, but one ought not to squeeze the throat of speculation so tightly that wrong things aren't allowed to be said, or fun to be had.

        [1] not saying the OP is right or wrong - I have no idea about that - but the article looks like the fun kind of meandering speculation that has a good place here.

        [2] [editing - bear with me...]

        https://news.ycombinator.com/item?id=11655206